安卓开发求职招聘微信群 https://www.edunews.net.cn/2021/ywbb_0912/131570.htmlTODAY今日发布JAHADec17,:8(24)今日发布04篇（共计49篇）AmJCardiovascDrugsEarlyRecent,Dec11,今日发布01篇HypertensionJan01,:75(1)今日发布34篇ATVBEarlyRecent,Dec12,今日发布04篇StrokeEarlyRecent,Dec12,今日发布13篇RECOMMEND推荐阅读01Bexarotene对实验性脑出血巨噬细胞吞噬功能及血肿清除的影响Strokeresearch-articleChe-FengChang,JordanMassey,etc.1小时前等49用户推荐阅读本文BackgroundandPurposeEnhancementoferythrophagocytosisbymacrophagesinatimelymannercanlimitthetoxiceffectsoferythrocytemetabolitesandpromotebrainrecoveryafterintracerebralhemorrhage(ICH).Inthecurrentstudy,weinvestigatedthetherapeuticeffectofretinoidXreceptoragonist,bexarotene,infacilitatingerythrophagocytosisandneurobehavioralrecoveryin2mousemodelsofICH.及时增强巨噬细胞吞噬功能可限制红细胞代谢物的毒性作用，促进脑出血（ICH）后脑功能的恢复。在本研究中，我们观察了维甲酸X受体激动剂bexarotene对2种小鼠脑出血模型红细胞吞噬和神经行为恢复的促进作用。MethodsBonemarrow-derivedmacrophagesandfluorescentlylabelederythrocyteswereusedtostudyerythrophagocytosisinvitrowithphenotypicchangesquantifiedbygeneexpression.ICHwasmodeledinvivousingintrastriatalautologousbloodandcollagenaseinjectioninmicewithandwithoutbexarotenetreatmentbeginning3hoursafterICH.Invivophagocytosis,abilityandhematomaclearancewereevaluatedbyerythrophagocytosisassays,flowcytometry,andhistologicalanalysis.Neurologicaldeficitsandfunctionalrecoverywerealsoquantified.用骨髓源性巨噬细胞和荧光标记的红细胞研究体外红细胞吞噬功能，并用基因表达定量分析其表型变化。从脑出血后3小时开始，用纹状体内自体血和胶原酶注射，在有或无贝沙芬治疗的小鼠体内建立脑出血模型。通过红细胞吞噬试验、流式细胞术和组织学分析，评估体内吞噬能力、清除血肿的能力。神经功能缺损和功能恢复也被量化。ResultsBexaroteneincreasedmacrophageexpressionofphagocytosisreceptorsanderythrophagocytosisandreducedmacrophageTNF(tumornecrosisfactor)productioninvitro.Invivo,bexarotenetreatmentenhancederythrophagocytosis,reducedhematomavolume,andultimatelyimprovedneurologicalrecoveryafterICHin2distinctmodelsofICH.Bexarotene增加巨噬细胞吞噬受体和红细胞吞噬功能的表达，减少巨噬细胞TNF（tumornecrosisfactor）的产生。在体内，在两种不同的脑出血模型中，贝沙罗汀治疗增强了红细胞吞噬功能，减少了血肿体积，并最终改善了脑出血后的神经恢复。ConclusionsBexaroteneadministrationisbeneficialforrecoveryafterICHbyenhancinghemorrhagephagocytosis,modulatingmacrophagephenotype,andimprovingfunctionalrecovery.Bexarotene通过增强出血吞噬功能，调节巨噬细胞表型，促进功能恢复，有利于脑出血后的恢复。扫描
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